|
|
5alpha-pregnane-3beta-ol-20-one + NADP+ <=> H+ + 5alpha-dihydroprogesterone + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.148
estradiol 17alpha-dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.270
3beta-hydroxysteroid 3-dehydrogenase
1.1.1.278
3beta-hydroxy-5alpha-steroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
|
MK
|
| |
BRENDA:
BR47593;
BS187716
KEGG:
R07138;
R08957
MetaCyc:
1.1.1.278-RXN;
RXN66-567
SABIO-RK:
13071
|
|
|
|
5alpha-pregnane-3beta-ol-20-one + NAD+ <=> 5alpha-dihydroprogesterone + NADH + H+
|
1.1
1.1.1.1
alcohol dehydrogenase
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
1.1.1.209
3(or 17)alpha-hydroxysteroid dehydrogenase
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.278
3beta-hydroxy-5alpha-steroid dehydrogenase
1.1.1.35
3-hydroxyacyl-CoA dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
–
–
–
–
–
–
–
|
|
| |
BRENDA:
BS257036;
BS257208-a
MetaCyc:
RXN66-567_WOP;
RXN66-570
SABIO-RK:
10143;
7759
|
|
|
|
5alpha-dihydroprogesterone + NADP+ <=> progesterone + NADPH + H+
|
1.3.1.22
3-oxo-5alpha-steroid 4-dehydrogenase (NADP+)
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
–
|
MK
|
| |
BRENDA:
BS258427
KEGG:
R02208
MetaCyc:
PROGESTERONE-5-ALPHA-REDUCTASE-RXN
SABIO-RK:
2180
|
|
|
|
5alpha-pregnan-20alpha-ol-3-one + NADP+ <=> 5alpha-dihydroprogesterone + NADPH
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
–
|
K
|
| |
BRENDA:
BS372151
KEGG:
R08958
|
|
|
|
5alpha-pregnan-20alpha-ol-3-one + NAD+ <=> 5alpha-dihydroprogesterone + NADH
|
1.1.1.149
20alpha-hydroxysteroid dehydrogenase
1.1.1.239
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
–
–
|
|
| |
BRENDA:
BS372151-a
SABIO-RK:
11976
|
|
|
|
5alpha-dihydroprogesterone + reduced_flavodoxin + O2 <=> 5alpha-pregnan-17alpha-ol-3,20-dione + flavin + H2O
|
1.14.14.32
17alpha-hydroxyprogesterone deacetylase
|
–
|
|
| |
BRENDA:
BS432635
|
|
|
|
5alpha-dihydroprogesterone + 2,6-dichlorophenolindophenol <=> 5alpha-pregn-1-en-3,20-dione + reduced_2,6-dichlorophenolindophenol
|
1.3.99.4
3-oxosteroid 1-dehydrogenase
|
–
|
|
| |
BRENDA:
BS396046
|
|
|
|
3alpha-tetrahydroprogesterone + NADH <=> 5alpha-dihydroprogesterone + NAD+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS257211
|
|
|
|
5beta-Pregnan-3beta-ol-20-one + NAD+ <=> 5alpha-dihydroprogesterone + NADH + H+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS396061-a
|
|
|
|
5alpha-dihydroprogesterone + NADH <=> 4-pregnen-3alpha,20beta-diol + NAD+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS370820-a
|
|
|
|
3alpha,5alpha-allopregnenolone + NAD+ <=> 5alpha-dihydroprogesterone + NADH
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
| |
BRENDA:
BS394649-a
|
|
|
|
5alpha-dihydroprogesterone + NADPH <=> 5beta-pregnane-3,20-dione + NADPH
|
1.1.1.145
3beta-hydroxy-Delta5-steroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS396051
|
|
|
|
5alpha-dihydroprogesterone + NADPH + H+ <=> allopregnanolone + 5alpha-pregnan-20alpha-ol-3-one + NADP+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS424602
|
|
|
|
5alpha-dihydroprogesterone + NADPH + H* <=> allopregnanolone + 5alpha-pregnan-20alpha-ol-3-one + NADP+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS372150
|
|
|
|
5beta-Pregnan-3beta-ol-20-one + NADP+ <=> 5alpha-dihydroprogesterone + NADPH + H+
|
1.1.1.51
3(or 17)beta-hydroxysteroid dehydrogenase
|
–
|
|
| |
BRENDA:
BS396061
|
|
|
|
5alpha-dihydroprogesterone + NADPH + O2 <=> 5alpha-pregnan-17alpha-ol-3,20-dione + NADP+ + H2O
|
1.14.14.19
steroid 17alpha-monooxygenase
|
–
|
|
| |
BRENDA:
BS376016
|
|
|
|
5alpha-dihydroprogesterone + NADPH <=> 4-pregnen-3alpha,20beta-diol + NADP+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS370820
|
|
|
|
5alpha-dihydroprogesterone + NADPH <=> 5alpha-hydroxy-pregnan-20-one + NADP+
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS372149
|
|
|
|
3alpha,5alpha-allopregnenolone + NADP+ <=> 5alpha-dihydroprogesterone + NADPH
|
1.1.1.213
3alpha-hydroxysteroid 3-dehydrogenase (Re-specific)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
|
|
| |
BRENDA:
BS394649
|
|
|
|
progesterone + reduced_acceptor <=> 5alpha-dihydroprogesterone + acceptor
|
1.3.99.5
3-oxo-5alpha-steroid 4-dehydrogenase (acceptor)
|
–
|
|
| |
BRENDA:
BS438426
|
|
